Anubha Anti-Ageing Medicine
ANUBHA NEWS  Jan/Feb 2011


Anti-Ageing Medicine at Anubha embraces both physical, mental and spiritual rejuvenation.
Skin ageing is affected by environmental influences, by lifestyle practices and by endogenous
factors like our genes and their encoded proteins including hormones as well as by non-
genetic factors like organ dysfunction.

As our skin ages, its ability to repair is reduced. Its recovery and versatility is compromised.
Worst of all it starts looking old and loses is sculptured beauty.
Removing or avoiding free-radicals from your immediate external environment (e.g. excess
sun) can slow the damage. However what we breathe, what we eat and our hormonal status
may also contribute to our skin health.

Genetics and epigenetics can impact skin vitality.
Genes and their encoded proteins which may benefit us when we are young, become a
menace as we age. This is known as pleomorphic antagonism.

Growth signaling proteins (kinases) support (beautiful) growth when young, promote signs
of ageing/disease or cancer later in life.
Blocking signal transduction of growth promoting kinases can block cancer or the signs of
ageing (wrinkles).

Unblocking suppressed (protective) genes supports skin and organ longevity.
genetic level to effect anti-ageing results.

Many chemical based anti-ageing products work on a superficial cellular level.
Pg & iso-PG act as GENETIC SWITCHES turning on silenced genes (silenced with ageing)
and turn off tumour promoting genes activated with ageing.

PG and iso-PG and phenylbutyrate are pro-drugs for naturally occuring amino-acid derivatives.
which were discovered Dr Stanislaw Burzynski in 1968 as part of his PhD thesis. They are
peptides which are small amino acid molecules, existing naturally in the human body and in
many foods.

Genomic profiling in ageing animals, shows upregulation in the IGF/AKT signaling pathway
and down regulation of PTEN  (increased risk cancer skin damage / cardiovascular disease).
Based on DNA microarray studies: PG decreases the activity of AKT2 (oncogene).
PG increases activity of PTEN (a tumour suppressor gene).
PG and iso-PG have been shown to unmethylate TSG's and methylate oncogenes improving
DNA stability and decreasing the potential risk of cancer as well as inhibition of deacetylation
of histones which allows (appropriate) gene expression.  

These anti-neoplastons precursors are now available in an amino-acid based cream/lotion.
This cosmoceutical cream and lotion  Aminocare has been developed by Dr Burzynski.

Active ingredients are: Phenylacetylglutamine (PG)  Phenylacetyl iso-glutamine (iso-PG),
which have a specific blocking effect on genes that promote skin ageing (AKT, IGF-1, RAS
and mTOR); stimulation of specific tumour suppressor genes (TSG's)-p16 and PTEN that have
been methylated and/or deacetylated.

4 week trial 22 volunteers no skin pathology apart from wrinkles
Applied Aminocare cream to one area of crow’s feet wrinkles (treated side)
Untreated side-control side
Variables: tolerance, efficacy, acceptibility were monitored
Tolerance: Pre-trial back patch test. No reaction to the product  =inclusion in trial.
Efficacy: Silicon imprint of treated and non-treated sides beginning and end of study- laser
profilometry measure skin topography wrinkle (depth/volume & complexity)
Acceptability: Questionnaires
TOLERANCE: No reactions-excellent tolerance
EFFICACY: End of trial wrinkle depth, volume complexity all improved
ACCEPTIBILITY: Responses-very satisfactory-softness, suppleness, skin comfort, ease of
application and penetration. 19/22 desired to continue product.

Antineoplastons may have an anti-tumour effect as well as an skin anti-ageing effect.
Wrinkle depth, complexity and volume appears to decrease, when applied two times daily.
Results through research can occur in 1 months time.

This cream and lotion is available through Anubha products.

To contact Anubha telephone 03 6239 1572
or email

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Dr Russell Cooper, or Anubha's Anti-Ageing Treatments.

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